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1.) Reduction of radiocaesium absorption by sheep consuming feed contaminated with fallout from Chernobyl.

Two compounds, a zeolite, clinoptilolite, and a ferrocyanide, potassium hexacyanocobalt (II) ferrate (II), were found to be the most effective absorbers of caesium in vitro. When used in vivo they significantly reduced the absorption of caesium by sheep fed contaminated herbage. These compounds did not alter the rate of excretion of pre-absorbed caesium, which varied with the time from cessation of contamination.

Phillippo M, Gvozdanovic S, Gvozdanovic D, Chesters JK, Paterson E, Mills CF Vet Rec [10/1988] 122(23):560-3. [lang:eng]

2.) Entrex: Anti-diarrheic drug based on purified natural clinoptilolite

AUTHORS: G. Rodriguez-Fuentes, M.A. Barlos, B. Cedre
    A new anti-diarrheic drug for humans has been developed based on the physical, chemical, technological, pharmacological, microbiological and clinical studies were successfully conducted to meet the requirements of the Cuban Drug Quality Agency. the most important results concerning the properties and biological mechanism of NZ are:
    a) Clinical study in diabetes patients with vascular impairments neuropathic diarrhea - This was a comparative study with diphenoxilate of atropine, an antimotility drug. The results did not show significant difference between the two drugs, which is remarkable because neuropathic diarrhea is a syndrome that affects patients with vascular impairments produced by diabetes mellitus. Thus the recovery of the patients must be achieved in the first 24 h, and this was made possible by application of Enterex therapy. It was demonstrated that a second dosage of our drug had no adverse side effects, contrary to diphenoxilate of atropine, which does not allow for a second dosage without adverse side effects.
    b) Clinical study in patients with acute diarrhea resulting from food intoxication. The main cause of acute diarrhea in adults is food intoxication, therefore, the fourth clinical study was conducted in a large population of volunteers (434) affected by this diarrhea. The result of the study shows that 75.6% of the patients recovered from diarrhea in the first 24 h and 24.4% in 36 h. These figures confirm the results obtained in previous studies such as a significant reduction in time for the physiological evolution of an acute diarrhea - 72 h - without adverse side effects.
SOURCE: Zeolites 19; 441-448, 1997

3.) Zeolite A increases proliferation, differentiation, and transforming growth factor beta production in normal adult human osteoblast-like cells in vitro.

AUTHORS: Keeting PE; Oursler MJ; Wiegand KE; Bonde SK Spelsberg TC; Riggs BL
AFFILIATION: Endocrine Research Unit, Mayo Clinic, Rochchester, Minnesota.
    Silicon in trace amounts enhances bone formation, and the silicon containing compound zeolite A (ZA) increases eggshell thickness in hens. In the studies reported here, treatment of nearly homogeneous strains of normal human osteoblast-like cells for 48 h with ZA at 0.1 - 100 micrograms/ml induced a dose-dependent increase (r = 0.35, P < 0.001) in DNA synthesis (n = 31) to 162 +/- 16% (mean +/- SEM) of control and in the proportion of cells in mitosis (n = 4) from 9.1 +/- 1.8 to 27.0 +/- 4.5% (r = .069, P < 0.005). ZA treatment also increased alkaline phosphatase activity (P < 0.05) and osteocalcin release (P < 0.05) but did not significantly affect collagen production per individual cell. The mitogenic action of ZA was dependent on cell seeding density over the range of 1250-40,000 cells per cm2, which is consistent with induction of an autocrine factor(s). TGF-beta is a potent mitogen for osteoblasts. ZA treatment increased the steady-date mRNA levels of transforming growth factor beta 1 (TGF-beta 1) and induced the release of the latent form of TGF-beta protein into the conditioned medium within 6 h. We conclude that ZA induces the proliferation and differentiation of cells of the osteoblasts lineage.
SOURCE: J Bone Miner Res 1992 Nov;7(11):1281-9

4.) Sorption characteristics of natural zeolite (clinoptilolite) in biological material in vitro]

AUTHORS: Vrzgula L; Seidel H
    The zeolite (clinoptilolite) sorption of arsenic, cadmium, and lead ions from rumen fluid and abomasum juice was investigated in laboratory conditions. Zeolite was found to sorb 91% of lead and 45% of cadmium from rumen fluid in 24 hours. The sorption effectiveness was even higher from abomasum juice where zeolite sorbed 98% lead in 24 hours.
SOURCE: Vet Med (Praha) 1989 Sep;34(9):537-44

5.) Natural zeolite clinoptilolite: new adjuvant in anticancer therapy.

Natural silicate materials, including zeolite clinoptilolite, have been shown to exhibit diverse biological activities and have been used successfully as a vaccine adjuvant and for the treatment of diarrhea. We report a novel use of finely ground clinoptilolite as a potential adjuvant in anticancer therapy. Clinoptilolite treatment of mice and dogs suffering from a variety of tumor types led to improvement in the overall health status, prolongation of life-span, and decrease in tumors size. Local application of clinoptilolite to skin cancers of dogs effectively reduced tumor formation and growth. In addition, toxicology studies on mice and rats demonstrated that the treatment does not have negative effects. In vitro tissue culture studies showed that finely ground clinoptilolite inhibits protein kinase B (c -Akt), induces expression of p21WAF1/CIP1 and p27KIP1 tumor suppressor proteins, and blocks cell growth in several cancer cell lines. These data indicate that clinoptilolite treatment might affect cancer growth by attenuating survival signals and inducing tumor suppressor genes in treated cells.

Paveli? K, Hadzija M, Bedrica L, Paveli? J, Diki? I, Kati? M, Kralj M, Bosnar MH, Kapitanovi? S, Poljak-Blazi M, Krizanac S, Stojkovi? R, Jurin M, Suboti? B, Coli? M
J Mol Med [07/2001] 78(12):708-20. [lang:eng]

6.) The effect of feeding clinoptilolite on the health status, blood picture and weight gain in pigs]

Under experimental conditions, the effect of the administration of 5% the Nizny Hrabovec locality was studied as exerted on the health condition, blood picture, weigh gains, fae ces production and odour in pigs and on the course of gastroenterites of alimentary origin affecting these animals. The administration of mixture A1 with a 5% zeolite supplement did not exert any undesired influence on the white or red blood picture and on the general condition of health; on the contrary, weight gains increased by 23% as compared with the controls. The faeces of the treated animals were normally shaped and the odour was just slight. The administration of zeolite to the animals with gastroenteritis had a favourable influence on the health condition and weight gains. Clinoptilolite as a non-traditional additive is a suitable means on improving nutrient conversion, of increasing the weight gains, of controlling diarrhoeas of alimentary origin and eliminating odour in large pig houses.

Vrgula L, Bartko P, Blazovsky J, Kozac J
Vet Med (Praha) [09/1982] 27(5):267-74. [lang:slo]

7.) The effect of natural zeolite on the excretion and distribution of radiocesium in rats]

Observation was made of the influence of natural zeolite (clinoptilolite) supplement in food on 134Cs excretion and distribution after oral internal contamination of laboratory brown rats. After diet administration with 2.5, 5, and 10% zeolite supplement the 134Cs elimination in droppings increased and the radionuclide deposition in liver, kidneys and femoral musculature decreased. The zeolite decontamination effects were observed with preventive administration, as well as with sorbent administration from the 24th hour after a single internal contamination.

Mizak P, Hrusovsky J, Tokosova M
Vet Med (Praha) [11/1989] 34(8):467-74. [lang:slo]

8.) Effects of natural zeolite-clinoptilolite on processes of removal of Cs-137 from the rat body]

The selectivity of natural and synthetic zeolites to 137Cs in experiments in vitro has been investigated. The influence of natural zeolite-clinoptilolite on the dynamics of withdrawal of 137Cs from rats' organism was estimated.

Krasnoperova AP, Lonin Alu
Radiats Biol Radioecol [11/19 99] 39(4):471-4. [lang:rus]

9.) Distribution of dichlorvos in the rat and the effect of clinoptilolite on poisoning]

In the first series of trials, the physiological values of tissue cholinesterases were determined in the male rats of the Wistar strain. In the second series of trials the rats were perorally intoxicated with dichlorvos at the doses of 200.0, 128.0, 81.9, 65.5 and 52.4 mg per kg live weight. The objective of the trials was to examine the distribution of dichlorvos in the body of a rat on the basis of tissue cholinesterase inhibition. A marked decrease in the level of tissue cholinesterases was recorded at all the dichlorvos doses. In the third series of trials the protective effect of clinoptilolite was verified; clinoptilolite as a sorbent of natural origin has been administered per os at the dose of 1.0 g per kg live weight just before the intoxication with dichlorvos. The results document a marked protective effect of clinoptilolite on most of the tissues studied.

Nistiar F, Hrusovsky J, Mojzis J, Mizik P
Vet Med (Praha) [03/1985] 29(11):689-98. [lang:slo]



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